Cisplatin efficacy

Author: peud

August undefined, 2024

WebApr 15, 2024 · A 64-year-old man exhibited lack of efficacy during treatment with pirarubicin, gemcitabine and cisplatin for metastatic, high-grade non-muscle invasive bladder urothelial carcinoma. Additionally, he also developed severe dizziness, nausea and vomiting during treatment with gemcitabine and cisplatin for metastatic high-grade non … WebNov 17, 2024 · Cisplatin has been widely used for a variety of cancer chemotherapies. In the guidelines for CINV, cisplatin is classified as a high-emetic-risk antineoplastic agent, and several agents – i.e. NK1 receptor antagonist (NK1RA), dexamethasone and 5-hydroxytryptamine-3 receptor antagonist (5-HT3RA) – are recommended for use with …

Enhancement of cisplatin efficacy by lipid–CaO2 …

WebJun 1, 2024 · A phase 2 trial of durvalumab in combination with gemcitabine and cisplatin demonstrated promising efficacy, with an objective response rate of 72% and a median overall survival of 20.2 months and without dose-limiting toxicity, in a nonrandomized, single-center study, establishing proof of concept for this approach in advanced biliary tract ... WebApr 5, 2024 · Concurrent chemoradiotherapy with 3-weekly cisplatin 100 mg/m 2 has been the standard of care for locoregionally advanced head and neck cancer (LA-HNC) with level I evidence. While the outcomes in terms of efficacy have been well established, the toxicity profile, compliance, and real-world applicability has been an area of ongoing concern for … imx6 end of life

Efficacy and tolerance of LV5FU2-carboplatin chemotherapy in …

WebSep 15, 2024 · Cisplatin has activity against multiple tumor types and was approved for use by the United States in 1978. Current indications include testicular, ovarian and bladder cancer. It is also used in combination with other agents in … WebSep 27, 2016 · PURPOSE Paclitaxel, ifosfamide, and cisplatin (TIP) achieved complete responses (CRs) in two thirds of patients with advanced germ cell tumors (GCTs) who relapsed after first-line chemotherapy with cisplatin and etoposide with or without bleomycin. We tested the efficacy of first-line TIP in patients with intermediate- or poor … WebApr 11, 2024 · Importantly, inhibition of STAT3 signaling significantly attenuated MB tumor growth in subcutaneous and intracranial orthotopic xenografts, increased the sensitivity of MB tumors to cisplatin, and improved the survival of … lithonia lighting fluorescent installation

Discovery – Cisplatin and The Treatment of Testicular …

Efficacy and toxicity of three concurrent chemoradiotherapy ... : …

WebJun 11, 2024 · PD is defined as ≥20% increase in the sum of diameters of target lesions. In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of ≥5 mm. The appearance of one or more new lesions is also considered PD. PFS as assessed by blinded independent central review (BICR) will be presented. WebMar 15, 2024 · The incidence of ototoxicity induced by cisplatin has been estimated to be 36% of adult patients with cancer and 40%-60% of pediatric patients.2 … lithonia lighting fluorescentWebThe efficacy of cisplatin must be improved for the treatment of UTUC because most patients with UTUC are older and may have renal insufficiency. The inadequate dose of cisplatin consequently leading to a poor outcome is a clinical challenge. lithonia lighting fluorescent fixture clip

"WebCisplatin for injection has been administered at 75 mg/m. 2 . to 100 mg/m. intravenously per cycle once every 3 to 4 weeks on Day 1. Other doses and combination regimens have … " - Cisplatin efficacy

Cisplatin efficacy

Clinical comparative investigation of efficacy and toxicity of ...

WebDec 30, 2024 · Another large cohort study by Zhu et al [ 21] reported that weekly cisplatin was associated with ... WebJul 3, 2024 · These include blockade of cisplatin entry into the cochlear fluid or hair cells. Further, antioxidants are among the most extensively studied agents due to the importance of ROS in ototoxicity. However, a concern exists that the chemotherapeutic efficacy of cisplatin may be reduced (Block et al., 2009). Reductions in inflammatory cytokine ...

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WebJul 30, 2024 · In this study, we proposed a comprehensive TME modulation strategy that modifies multiple elements of the TME in order to enhance cisplatin anticancer efficacy. … WebCisplatin : an old drug with a newfound efficacy -- from mechanisms of action to cytotoxicity Although cisplatin has been used for a long time, only recently its exact mechanism of action has been better defined.

WebJul 8, 2024 · Multicenter, randomized, open-label, parallel group phase 2 study to assess the efficacy and tolerance of four combinations of CBP501, cisplatin, and nivolumab administered once every 21 days to patients with stage IV exocrine pancreatic cancer and WBC < 10,000/mm3 at screening. WebSep 20, 2024 · Efficacy was evaluated in two multicenter open-label, randomized controlled trials in pediatric patients undergoing treatment with cisplatin-based chemotherapy for …

WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. ... 11 with an overall … WebThe TPF triplet regimen (docetaxel, cisplatin, and 5‐FU) has a trend of further improving treatment efficacy compared with the traditional doublet regimen. 35 , 36 In a phase II …

WebCisplatin and nimotuzumab combined with concurrent chemoradiotherapy is safe and effective in the treatment of locally advanced cervical cancer, both local tumor control and PFS rate are excellent, and the patient's tolerance is good, so it …

WebChemotherapeutics that damage DNA, such as cisplatin, have been the mainstay of cancer treatment for decades . However, all too often the efficacy of such DNA-damaging chemotherapy is severely limited by intrinsic and acquired drug resistance, as well as by the induction of secondary malignancies. imx6 buildrootWebOct 5, 2014 · Cisplatin is cleared by the kidney by both glomerular filtration and tubular secretion (Yao, Panichpisal et al., 2007; Ishida, Lee et al., 2002) Cisplatin … lithonia lighting fluorescent fixturesWebotoprotective effect, with maximum efficacy oc-curring when sodium thiosulfate is administered 4 to 8 hours after cisplatin,13-20 and that the ... be treated with cisplatin alone, they represent an imx6_l4.1.15_2.0.0_mfg_toolWebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. ... 11 with an overall five-year survival of just 16%. 12 Therefore, improving the efficacy of DDP chemotherapy and sequential treatment after the failure of the DDP chemotherapy is crucial to ... imx6 pmic_on_reqWebJan 13, 2024 · Indeed, after decades of research on antioxidants optimized for scheduling, dose, potency, and method of administration, no antioxidant therapy has demonstrated enough efficacy to be widely accepted as a therapy for cisplatin ototoxicity. Despite some limitations of antioxidants, several have moved toward a clinical trial. imx6 bluetooth xbox oneWebThe dose of cisplatin was reduced in 26 of 82 patients (31.7%) in the EP arm and in 25 of 82 patients (30.5%) in the IP arm. The mean (range) DI of cisplatin was 21.9 (14.3-26.8) mg/m 2 /wk in the EP arm and 13.6 (9.9 … imx6 lvds display configurationWebApr 11, 2024 · To evaluate if STAT3 KD can enhance the efficacy of cisplatin therapy for MB, we treated HD-shSTAT3 and ONS-shSTAT3 cells with an increasing concentration … lithonia lighting fluorescent round lb232