Plzf transcription factor

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WebJul 28, 2009 · The PLZF transcription factor is essential for the innate phenotype of NKT cells. This report shows that PLZF is likewise responsible for the innate, NKT-like … WebApr 1, 2016 · PLZF (Promyelocytic Leukemia Zinc Finger) is a BTB-POZ transcription factor. Two co-orthologs of the human PLZF are found in teleost fish species. Zebrafish Plzf …

Role of PLZF as a tumor suppressor in prostate cancer

WebApr 14, 2024 · The kpc-1 gene encodes a conserved proprotein convertase KPC-1/FURIN whereas eor-1 encodes for the zinc finger transcription factor EOR-1/PLZF. Both LOF mutants exhibit TSC persistence with cell body rounding in L1 C. elegans larvae that are consistent with the ns957 phenotype. Additionally, all three of these mutants appear to … WebPlzf (Promyelocytic Leukaemia Zinc-Finger) is one of the first transcription factor shown to be required for self-renewal of SSCs [ 7] and is also co-expressed along with Oct-4 in undifferentiated spermatogonia [ 13 ]. Plzf is expressed during embryogenesis and plays a crucial role during limb and axial skeletal patterning. extra wide leather office chair

Driving the degradation of oncofusion proteins for targeted cancer ...

WebJul 30, 2015 · Among a number of transcription factors identified to date, NF-κB still remains the most prominent and studied factor for its diverse range of selective transcriptional activities. ... The transcriptional regulator PLZF is a critical co-factor that limits NF-κB-mediated inflammatory responses by maintaining a transcriptionally … WebSep 19, 2008 · We report that PLZF (promyelocytic leukemia zinc finger, Zbtb16), a member of the BTB/POZ-ZF family of transcription factors that includes the CD4-lineage-specific c … WebPLZF was shown to be phosphorylated by cdc2/Cyclin-B in vitro, which affected its DNAbinding ability to the promoter of many transcription factors such as c-Jun and GATA1 (Ball et al., 1999 ... doctor who the tenth planet dvd

Promyelocytic leukaemia zinc finger protein (PLZF) is a

PLZF Regulates Fibroblast Growth Factor Responsiveness and

Web2 days ago · In return, PLZF/RARα is likely to activate the expression of USP37. 18 Accordingly, ... [69], [70] The transcription factor MEF2D is a member of the myocyte enhancer factor 2 (MEF2) family, and MEF2D fusion occurs in approximately 5% of B-cell acute lymphoblastic leukemia (ALL) cases. WebJul 18, 2015 · The promyelocytic leukemia zinc finger (PLZF), also known as ZBTB16 (Zinc Finger And BTB Domain Containing 16), is a transcription factor involved in the regulation of diverse biological... extra wide leather watch bandsWebFunction [ edit] This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger … doctor who the time machine

"WebOct 8, 2013 · Here, we show that the transcription factor Promyelocytic Leukemia Zinc Finger (PLZF) plays a critical role shaping patterns of neuronal differentiation by gating … " - Plzf transcription factor

Plzf transcription factor

The transcription factor PLZF (Zbtb16) directs the

WebJan 20, 2024 · Critical transcription factors regulate ILC development.After the stage of common lymphoid progenitor (CLP), transcription factors such as TCF1, TOX and Nfil3, together with the Notch signals, promote the generation of an early innate lymphoid progenitor (EILP) expressing Integrin α 4 β 7.EILP has the potential to become both the … WebOct 8, 2013 · PLZF is a member of the BTB/POZ family of transcription factors known to regulate progenitor maintenance in multiple tissues [25]. PLZF was initially identified as a protein whose functions are subverted through chromosomal rearrangements resulting in acute promyelocytic leukemia [26].

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WebNational Center for Biotechnology Information WebWe found that let-7 miRNAs targeted Zbtb16 mRNA, which encodes the lineage-specific transcription factor PLZF, to post-transcriptionally regulate PLZF expression and thereby …

WebJan 9, 2024 · The promyelocytic leukemia zinc finger (PLZF) transcription factor mediates a wide‐range of biological processes. Accordingly, perturbation of PLZF function results in a myriad of physiologic defects, the most conspicuous of which is … WebNov 11, 2024 · PLZF is a transcription factor involved in multiple biological processes such as neurogenesis, spermatogenesis, invariant natural killer T-cell development, and leukemogenesis 25, 30, 31, 32....

WebJul 4, 2010 · PLZF (promyelocytic leukemia zinc finger; Zbtb16) has been identified as a key transcription factor involved in the development of NKT cells 5, 6, yet it remains unclear if …

WebInvariant natural killer T cells (iNKT cells) are lipid-sensing innate T cells that are restricted by the antigen-presenting molecule CD1d and express the transcription factor PLZF. iNKT …

WebApr 14, 2024 · The kpc-1 gene encodes a conserved proprotein convertase KPC-1/FURIN whereas eor-1 encodes for the zinc finger transcription factor EOR-1/PLZF. Both LOF … extra wide leg compression sleeveWebApr 14, 2024 · NF-κB Response Moderation by Regulating the Transcription Factor PLZF Sadler et al. described a novel role for HAT1, namely, the acetylation of the transcriptional regulator promyelocytic leukemia zinc finger protein (PLZF), a critical cofactor of the NF-kB transcriptional complex that inhibits damaging inflammation [ 39 ]. extra wide leather work bootsWebMar 2, 2024 · The transcription factor PLZF directs the effector program of the NKT cell lineage. Immunity 29, 391–403 (2008). Article CAS Google Scholar Lazarevic, V. et al. The gene encoding early growth ... doctor who the time of the doctor 2013 movieWebdevelopment under the control of the transcription factor PLZF (promyelocytic leukemia zinc finger, encoded by Zbtb16). To elucidate the mechanisms underlying this unique … doctor who the timeless children castWebHence, for the first time we have identified a transcription factor that is crucial for the development of CD8 + Treg cells. Also importantly, since PLZF is stable and not inducible … doctor who the time of the doctor 2013WebJan 20, 2015 · PLZF belongs to the Broad-complex, Tramtrack and Bric-a-brac/poxvirus and zinc finger (BTB/POZ) family of transcription factors that regulate a variety of biological processes, including development, differentiation, tumorigenesis and, as is emerging, the immune response (10–13). doctor who the time lord victoriousWebApr 24, 2024 · Among these are transcription factors (TFs), an important class of proteins that regulate the occurrence, formation, and development of tumors. It is difficult for SMDs and macromolecular drugs to identify bioactive sites in TFs and hence for use as pharmacological inhibitors in targeting TF proteins. doctor who the time warrior dvd